Mitotic origins of chromosomal instability in colorectal cancer
نویسندگان
چکیده
منابع مشابه
Characterization of Chromosomal Instability in Murine Colitis-Associated Colorectal Cancer
BACKGROUND Patients suffering from ulcerative colitis (UC) bear an increased risk for colorectal cancer. Due to the sparsity of colitis-associated cancer (CAC) and the long duration between UC initiation and overt carcinoma, elucidating mechanisms of inflammation-associated carcinogenesis in the gut is particularly challenging. Adequate murine models are thus highly desirable. For human CACs a ...
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chromosomes, with only 2–6% anaphase CIN-cells displaying lagging chromosomes compared to 12–17% anaphase CIN+ cells (Figure 1B). CIN+ cells also contained multiple lagging chromosomes per anaphase, whereas multiple lagging chromosomes were rarely observed in CIN-cells (not shown). Very few acentric fragments were observed in anaphase for both CIN-and CIN+ cells, and this result was also confir...
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abstract: colorectal cancer (crc) is the third most common cancer in men and the second most common cancer in women worldwide. both genetic and epigenetic alterations are common in crc and are the driving force of tumorigenesis. chromosomal instability, microsatellite instability and cpg island methylator phenotype pathways are responsible for genetic instability in colorectal cancer. chromosom...
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PURPOSE Most breast cancers have chromosomal instability that seems related to defective mitotic spindle checkpoints. Because the molecular basis of this defect is unknown, we evaluated breast cancer cell lines and tissues for possible defects involving the major mitotic checkpoint genes responsible for maintaining chromosomal stability. EXPERIMENTAL DESIGN We analyzed sequences and expressio...
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Background: Colorectal cancer (CRC) is the third most common cancer worldwide. microsatellite instability (MSI) is a molecular marker of a deficient mismatch repair system and happens in almost 15% of CRCs. Because of a wide frequency of MSI+ CRC in Iran compared to other parts of the world, the importance of screening for this type of cancer is highlighted. Methods: The most common MSI detecti...
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ژورنال
عنوان ژورنال: Current Colorectal Cancer Reports
سال: 2007
ISSN: 1556-3790,1556-3804
DOI: 10.1007/s11888-007-0001-y